Microsecond Generation of Oxygen-bound Cytochrome c Oxidase by Rapid Solution Mixing
نویسندگان
چکیده
منابع مشابه
Oxygen Reduction and Proton Translocation by Cytochrome C Oxidase
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متن کاملCarbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species.
Carbon monoxide (CO), which is produced endogenously in the breakdown of heme, has been recognized as an important physiological second messenger similar to NO. Additionally, pharmacological delivery of CO is protective in numerous models of injury, including ischemia/reperfusion, transplantation, hemorrhagic shock, and endotoxemia. However, the mechanism of action of CO is only partially eluci...
متن کاملStructure/function of oxygen-regulated isoforms in cytochrome c oxidase.
Eukaryotic cytochrome c oxidases are complex oligomeric membrane proteins composed of subunit polypeptides encoded by both nuclear and mitochondrial genomes. While the mitochondrially encoded subunits are encoded by unique genes, some of the nuclear-encoded subunits are encoded by multigene families. The isoforms produced by these multigene families are tissue-specific and/or developmentally re...
متن کاملInhibition of cytochrome c oxidase by sulphide.
of the detergents used (Evans, 1956), although the sharp cut-off in activity evident lends support to the idea that protein denaturation by anionic detergents involves the formation of protein-detergent micelles (Tanford, 1970). The most effective inhibitor of glucuronidase activity was sodium tridecyl sulphate, whereas sodium pentadecyl sulphate exerted the strongest effects on the sulphatase....
متن کاملRedox transitions between oxygen intermediates in cytochrome-c oxidase.
Some intermediates in the reduction of O2 to water by cytochrome-c oxidase have been characterized by optical, Raman, and magnetic circular dichroism spectroscopy. The so-called "peroxy" (P) and "ferryl" (F) forms of the enzyme, which have been considered to be intermediates of the oxygen reaction, can be generated when the oxidized enzyme reacts with H2O2, or when the two-electron reduced ("CO...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.15.8405